Analysis Examples# Activation of Kinases in Controlled Cell Lines# EGF Stimulation of 184A1 Cells (Wolf Yadlin, 2007) Agglomerative clustering of kinases Agglomerative clustering of only significant kinases EGF and HRG Stimulation of ERBB2 Overexpressing HMEC Cells (Wolf Yadlin 2006) Plot all samples and kinases Plot just EGF HMEC data for comparison to MRM experiment Reshape results and plot to compare kinase between conditions TCR Activation (Chylek, 2014) Agglomerative clustering of kinases Agglomerative clustering of all significant kinases Inhibition of Kinases in Controlled Cell Lines# BCR-ABL inhibition by dasatinib in K562 cells (Asmussen, 2014) Plot kinases sorted by activity pre-treatment Plot kinases sorted by activity pre-treatment, but with only significant kinases Inhibition of AKT by Five Different Inhibitors in Breast Cancer (Weichmann, 2021) Plot and cluster kinase activities Plot and cluster kinase activities, but with only significant kinases Paradoxical Activation of MAP-ERK pathway upon BRAF inhibition (Kubiniok, 2017) Shared agglomerative clustering of kinases for both Colo205 and HCT116 cells Shared agglomerative clustering of significant kinases for both Colo205 and HCT116 cells Profiling HER2 therapy response in Breast Cancer# Analysis of CPTAC Breast Cancer Patient Samples (Mertens 2016) Plot using agglomerative clustering on both kinases and patients, and add context to each sample Plot ERBB2 activities with each samples associated HER2 status Measure the number of cross-predictions between HER2-status and HER2/ERBB2 activity Analysis of PDX Tumor Samples (Huang 2017) Plot all samples and all kinases, with HER2 status context Plot all samples and all significant kinases, with HER2 status context Analysis of HER2 Positive Patients using Microbiopsies (Satpathy 2021) Agglomerative clustering of all patients and kinases, with context Agglomerative clustering of all patients and all significant kinases, with context Plot only pre-treatment samples and provide treatment response context Plot specific kinases for each patient (all samples)