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PTM-POSE
Overview:
Overview
Dependencies
PTM-POSE Reference
Instructions:
Installation
Running PTM-POSE
Filtering PTMs and Events
Annotating PTMs with Functional Information
Example Vignettes
Examples
ESRP1 Knockdown (MATS output)
ESRP1 Expression in Prostate Cancer (TCGASpliceSeq output)
Analysis Gallery
Gallery
General Overview of Spliced PTMs
Inspecting types of PTMs impacted by splicing
Inspecting number of PTMs with annotation information available
Impact of filtering PTMs
Functional Impact of Spliced PTMs
Identifying available PTM-specific annotation information
Identify enriched gene sets associated with differentially spliced PTMs
Assessing enriched PTM functions
Impact on protein interaction and regulatory networks
Kinase substrate enrichment analysis (KSEA)
Protein interactions network
Identify kinases with enriched substrates in differentially included exons, using an adapted version of KSTAR
Analyzing altered flanking sequences
Inspect difference of flanking sequence due to splice event
Identify altered SH2 domain motifs
Probing where and how PTM flanking sequences are altered
Kinase affinity due to PTM flanking sequence alterations
Troubleshooting
Frequently Asked Questions
.rst
.pdf
Examples
Examples
#
ESRP1 Knockdown (MATS output)
ESRP1 Expression in Prostate Cancer (TCGASpliceSeq output)