Tutorial

Network Generation

• Network Generation
  • Download pre-generated networks
  • Generate your own networks

Activity Prediction

• Map Datasets to KinPred
  • Download and Process Dataset of Interest
  • Map the Dataset to KinPred
  • Explore the Mapped Dataset
• Predict Kinase Activities
  • Determine Thresholds
  • Calculate Statistical Enrichment (Hypergeometric p-values)
  • Generate random datasets, run kinase activity on random datasets, normalize original analysis
  • Calculate Mann Whitney Significance
  • Save KSTAR Results

Plotting

• Plotting
  • With Interactive Web App
  • In Python

Additional Analyses

• Assessing KSTAR Networks and Activity Predictions
  • Load results and other necessary data (networks, binary evidence, etc.)
  • Identify relevant phosphorylation sites for a kinase of interest
  • Exploring Network and Experiment Coverage of Phosphorylation Sites